A pragmatic randomized controlled trial of group transdiagnostic cognitive-behaviour therapy for anxiety disorders in primary care: study protocol.
Identifieur interne : 000A39 ( Main/Exploration ); précédent : 000A38; suivant : 000A40A pragmatic randomized controlled trial of group transdiagnostic cognitive-behaviour therapy for anxiety disorders in primary care: study protocol.
Auteurs : Pasquale Roberge [Canada] ; Martin D. Provencher [Canada] ; Patrick Gosselin [Canada] ; Helen-Maria Vasiliadis [Canada] ; Isabelle Gaboury [Canada] ; Annie Benoit [Canada] ; Martin M. Antony [Canada] ; Nils Chaillet [Canada] ; Janie Houle [Canada] ; Catherine Hudon [Canada] ; Peter J. Norton [Australie]Source :
- BMC psychiatry [ 1471-244X ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Agoraphobie (diagnostic), Agoraphobie (psychologie), Agoraphobie (thérapie), Autorapport (MeSH), Femelle (MeSH), Humains (MeSH), Mâle (MeSH), Psychothérapie de groupe (méthodes), Qualité de vie (psychologie), Québec (épidémiologie), Résultat thérapeutique (MeSH), Soins de santé primaires (méthodes), Thérapie cognitive (méthodes), Troubles anxieux (psychologie), Troubles anxieux (thérapie), Troubles anxieux (épidémiologie).
- MESH :
- diagnostic : Agoraphobie.
- méthodes : Psychothérapie de groupe, Soins de santé primaires, Thérapie cognitive.
- psychologie : Agoraphobie, Qualité de vie, Troubles anxieux.
- thérapie : Agoraphobie, Troubles anxieux.
- épidémiologie : Québec, Troubles anxieux.
- Adulte, Autorapport, Femelle, Humains, Mâle, Résultat thérapeutique.
English descriptors
- KwdEn :
- Adult (MeSH), Agoraphobia (diagnosis), Agoraphobia (psychology), Agoraphobia (therapy), Anxiety Disorders (epidemiology), Anxiety Disorders (psychology), Anxiety Disorders (therapy), Cognitive Behavioral Therapy (methods), Female (MeSH), Humans (MeSH), Male (MeSH), Primary Health Care (methods), Psychotherapy, Group (methods), Quality of Life (psychology), Quebec (epidemiology), Self Report (MeSH), Treatment Outcome (MeSH).
- MESH :
- geographic , epidemiology : Quebec.
- diagnosis : Agoraphobia.
- epidemiology : Anxiety Disorders.
- methods : Cognitive Behavioral Therapy, Primary Health Care, Psychotherapy, Group.
- psychology : Agoraphobia, Anxiety Disorders, Quality of Life.
- therapy : Agoraphobia, Anxiety Disorders.
- Adult, Female, Humans, Male, Self Report, Treatment Outcome.
Abstract
BACKGROUND
Anxiety disorders are the most common mental disorders in community settings, and they are associated with significant psychological distress, functional and social impairment. While cognitive behaviour therapy (CBT) is the most consistently efficacious psychological treatment for anxiety disorders, barriers preclude widespread implementation of CBT in primary care. Transdiagnostic group CBT (tCBT) focuses on cognitive and behavioural processes and intervention strategies common to different anxiety disorders, and could be a promising alternative to conventional CBT. This study aims to examine the effectiveness of a transdiagnostic group CBT for anxiety disorders program as a complement to treatment-as-usual (TAU) in primary mental health care.
METHODS/DESIGN
The trial is a multicentre pragmatic randomized controlled trial with a pre-treatment, post-treatment, and follow-up at 4, 8 and 12-months design. Treatment and control groups. a) tCBT (12 weekly 2-h group sessions following a manualized treatment protocol); b) TAU for anxiety disorders. Inclusion criteria comprise meeting DSM-5 criteria for primary Panic Disorder, Agoraphobia, Social Anxiety Disorder and/or Generalized Anxiety Disorder. Patients are recruited in three regions in the province of Quebec, Canada. The primary outcome measures are the self-reported Beck Anxiety Inventory and the clinician-administered Anxiety and Related Disorders Interview Schedule for DSM-5 (ADIS-5); secondary outcome measures include treatment responder status based on the ADIS-5, and self-reported instruments for specific anxiety and depression symptoms, quality of life, functioning, and service utilisation.
STATISTICAL ANALYSIS
Intention-to-treat analysis. A mixed effects regression model will be used to account for between- and within-subject variations in the analysis of the longitudinal effects of the intervention.
DISCUSSION
This rigorous evaluation of tCBT in the real world will provide invaluable information to decision makers, health care managers, clinicians and patients regarding the effectiveness of the intervention. Widespread implementation of tCBT protocols in primary care could lead to better effectiveness, efficiency, access and equity for the large number of patients suffering from anxiety disorders that are currently not obtaining evidence-based psychotherapy.
TRIAL REGISTRATION
ClinicalTrials.gov: NCT02811458 .
DOI: 10.1186/s12888-018-1898-1
PubMed: 30285672
PubMed Central: PMC6169021
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Antony</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3</wicri:regionArea><wicri:noRegion>M5B 2K3</wicri:noRegion></affiliation></author><author><name sortKey="Chaillet, Nils" sort="Chaillet, Nils" uniqKey="Chaillet N" first="Nils" last="Chaillet">Nils Chaillet</name><affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics, Gynecology, and Reproduction, Université Laval, 2705, boulevard Laurier, Québec, QC, G1V 4G2, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Obstetrics, Gynecology, and Reproduction, Université Laval, 2705, boulevard Laurier, Québec, QC, G1V 4G2</wicri:regionArea><orgName type="university">Université Laval</orgName><placeName><settlement type="city">Québec (ville)</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Houle, Janie" sort="Houle, Janie" uniqKey="Houle J" first="Janie" last="Houle">Janie Houle</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, Université du Québec à Montréal, C.P. 8888, succ. Centre-ville, Montréal, QC, H3C 3P8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, Université du Québec à Montréal, C.P. 8888, succ. 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Norton</name><affiliation wicri:level="1"><nlm:affiliation>Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton Campus, Clayton, VIC, 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton Campus, Clayton, VIC, 3800</wicri:regionArea><wicri:noRegion>3800</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30285672</idno><idno type="pmid">30285672</idno><idno type="doi">10.1186/s12888-018-1898-1</idno><idno type="pmc">PMC6169021</idno><idno type="wicri:Area/Main/Corpus">000703</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000703</idno><idno type="wicri:Area/Main/Curation">000703</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000703</idno><idno type="wicri:Area/Main/Exploration">000703</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A pragmatic randomized controlled trial of group transdiagnostic cognitive-behaviour therapy for anxiety disorders in primary care: study protocol.</title><author><name sortKey="Roberge, Pasquale" sort="Roberge, Pasquale" uniqKey="Roberge P" first="Pasquale" last="Roberge">Pasquale Roberge</name><affiliation wicri:level="1"><nlm:affiliation>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada. Pasquale.Roberge@USherbrooke.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Provencher, Martin D" sort="Provencher, Martin D" uniqKey="Provencher M" first="Martin D" last="Provencher">Martin D. Provencher</name><affiliation wicri:level="4"><nlm:affiliation>École de psychologie, Pavillon Félix-Antoine-Savard, 2325, rue des Bibliothèques, Université Laval, Québec, QC, G1V 0A6, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>École de psychologie, Pavillon Félix-Antoine-Savard, 2325, rue des Bibliothèques, Université Laval, Québec, QC, G1V 0A6</wicri:regionArea><orgName type="university">Université Laval</orgName><placeName><settlement type="city">Québec (ville)</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Gosselin, Patrick" sort="Gosselin, Patrick" uniqKey="Gosselin P" first="Patrick" last="Gosselin">Patrick Gosselin</name><affiliation wicri:level="1"><nlm:affiliation>Institut universitaire de première ligne en santé et services sociaux (CIUSSS de l'Estrie- CHUS), Department of Psychology, Université de Sherbrooke, 2500, boulevard de l'Université, Sherbrooke, QC, J1K 2R1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institut universitaire de première ligne en santé et services sociaux (CIUSSS de l'Estrie- CHUS), Department of Psychology, Université de Sherbrooke, 2500, boulevard de l'Université, Sherbrooke, QC, J1K 2R1</wicri:regionArea><wicri:noRegion>J1K 2R1</wicri:noRegion></affiliation></author><author><name sortKey="Vasiliadis, Helen Maria" sort="Vasiliadis, Helen Maria" uniqKey="Vasiliadis H" first="Helen-Maria" last="Vasiliadis">Helen-Maria Vasiliadis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Community Health Sciences, Université de Sherbrooke, Centre de recherche Hôpital Charles LeMoyne, 3120, boul. Taschereau, Greenfield Park, QC, J4V 2H1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Community Health Sciences, Université de Sherbrooke, Centre de recherche Hôpital Charles LeMoyne, 3120, boul. Taschereau, Greenfield Park, QC, J4V 2H1</wicri:regionArea><wicri:noRegion>J4V 2H1</wicri:noRegion></affiliation></author><author><name sortKey="Gaboury, Isabelle" sort="Gaboury, Isabelle" uniqKey="Gaboury I" first="Isabelle" last="Gaboury">Isabelle Gaboury</name><affiliation wicri:level="1"><nlm:affiliation>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Benoit, Annie" sort="Benoit, Annie" uniqKey="Benoit A" first="Annie" last="Benoit">Annie Benoit</name><affiliation wicri:level="1"><nlm:affiliation>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Antony, Martin M" sort="Antony, Martin M" uniqKey="Antony M" first="Martin M" last="Antony">Martin M. Antony</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychology, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3</wicri:regionArea><wicri:noRegion>M5B 2K3</wicri:noRegion></affiliation></author><author><name sortKey="Chaillet, Nils" sort="Chaillet, Nils" uniqKey="Chaillet N" first="Nils" last="Chaillet">Nils Chaillet</name><affiliation wicri:level="4"><nlm:affiliation>Department of Obstetrics, Gynecology, and Reproduction, Université Laval, 2705, boulevard Laurier, Québec, QC, G1V 4G2, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Obstetrics, Gynecology, and Reproduction, Université Laval, 2705, boulevard Laurier, Québec, QC, G1V 4G2</wicri:regionArea><orgName type="university">Université Laval</orgName><placeName><settlement type="city">Québec (ville)</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Houle, Janie" sort="Houle, Janie" uniqKey="Houle J" first="Janie" last="Houle">Janie Houle</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, Université du Québec à Montréal, C.P. 8888, succ. Centre-ville, Montréal, QC, H3C 3P8, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Psychology, Université du Québec à Montréal, C.P. 8888, succ. Centre-ville, Montréal, QC, H3C 3P8</wicri:regionArea><orgName type="university">Université du Québec à Montréal</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Hudon, Catherine" sort="Hudon, Catherine" uniqKey="Hudon C" first="Catherine" last="Hudon">Catherine Hudon</name><affiliation wicri:level="1"><nlm:affiliation>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4</wicri:regionArea><wicri:noRegion>J1H 5N4</wicri:noRegion></affiliation></author><author><name sortKey="Norton, Peter J" sort="Norton, Peter J" uniqKey="Norton P" first="Peter J" last="Norton">Peter J. Norton</name><affiliation wicri:level="1"><nlm:affiliation>Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton Campus, Clayton, VIC, 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton Campus, Clayton, VIC, 3800</wicri:regionArea><wicri:noRegion>3800</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC psychiatry</title><idno type="eISSN">1471-244X</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Agoraphobia (diagnosis)</term><term>Agoraphobia (psychology)</term><term>Agoraphobia (therapy)</term><term>Anxiety Disorders (epidemiology)</term><term>Anxiety Disorders (psychology)</term><term>Anxiety Disorders (therapy)</term><term>Cognitive Behavioral Therapy (methods)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Primary Health Care (methods)</term><term>Psychotherapy, Group (methods)</term><term>Quality of Life (psychology)</term><term>Quebec (epidemiology)</term><term>Self Report (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Agoraphobie (diagnostic)</term><term>Agoraphobie (psychologie)</term><term>Agoraphobie (thérapie)</term><term>Autorapport (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Psychothérapie de groupe (méthodes)</term><term>Qualité de vie (psychologie)</term><term>Québec (épidémiologie)</term><term>Résultat thérapeutique (MeSH)</term><term>Soins de santé primaires (méthodes)</term><term>Thérapie cognitive (méthodes)</term><term>Troubles anxieux (psychologie)</term><term>Troubles anxieux (thérapie)</term><term>Troubles anxieux (épidémiologie)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Quebec</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Agoraphobia</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Agoraphobie</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anxiety Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cognitive Behavioral Therapy</term><term>Primary Health Care</term><term>Psychotherapy, Group</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Psychothérapie de groupe</term><term>Soins de santé primaires</term><term>Thérapie cognitive</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Agoraphobie</term><term>Qualité de vie</term><term>Troubles anxieux</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Agoraphobia</term><term>Anxiety Disorders</term><term>Quality of Life</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Agoraphobia</term><term>Anxiety Disorders</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Agoraphobie</term><term>Troubles anxieux</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Québec</term><term>Troubles anxieux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Self Report</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Autorapport</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Anxiety disorders are the most common mental disorders in community settings, and they are associated with significant psychological distress, functional and social impairment. While cognitive behaviour therapy (CBT) is the most consistently efficacious psychological treatment for anxiety disorders, barriers preclude widespread implementation of CBT in primary care. Transdiagnostic group CBT (tCBT) focuses on cognitive and behavioural processes and intervention strategies common to different anxiety disorders, and could be a promising alternative to conventional CBT. This study aims to examine the effectiveness of a transdiagnostic group CBT for anxiety disorders program as a complement to treatment-as-usual (TAU) in primary mental health care.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS/DESIGN</b></p><p>The trial is a multicentre pragmatic randomized controlled trial with a pre-treatment, post-treatment, and follow-up at 4, 8 and 12-months design. Treatment and control groups. a) tCBT (12 weekly 2-h group sessions following a manualized treatment protocol); b) TAU for anxiety disorders. Inclusion criteria comprise meeting DSM-5 criteria for primary Panic Disorder, Agoraphobia, Social Anxiety Disorder and/or Generalized Anxiety Disorder. Patients are recruited in three regions in the province of Quebec, Canada. The primary outcome measures are the self-reported Beck Anxiety Inventory and the clinician-administered Anxiety and Related Disorders Interview Schedule for DSM-5 (ADIS-5); secondary outcome measures include treatment responder status based on the ADIS-5, and self-reported instruments for specific anxiety and depression symptoms, quality of life, functioning, and service utilisation.</p></div><div type="abstract" xml:lang="en"><p><b>STATISTICAL ANALYSIS</b></p><p>Intention-to-treat analysis. A mixed effects regression model will be used to account for between- and within-subject variations in the analysis of the longitudinal effects of the intervention.</p></div><div type="abstract" xml:lang="en"><p><b>DISCUSSION</b></p><p>This rigorous evaluation of tCBT in the real world will provide invaluable information to decision makers, health care managers, clinicians and patients regarding the effectiveness of the intervention. Widespread implementation of tCBT protocols in primary care could lead to better effectiveness, efficiency, access and equity for the large number of patients suffering from anxiety disorders that are currently not obtaining evidence-based psychotherapy.</p></div><div type="abstract" xml:lang="en"><p><b>TRIAL REGISTRATION</b></p><p>ClinicalTrials.gov: NCT02811458 .</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30285672</PMID><DateCompleted><Year>2019</Year><Month>09</Month><Day>16</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>16</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-244X</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>10</Month><Day>03</Day></PubDate></JournalIssue><Title>BMC psychiatry</Title><ISOAbbreviation>BMC Psychiatry</ISOAbbreviation></Journal><ArticleTitle>A pragmatic randomized controlled trial of group transdiagnostic cognitive-behaviour therapy for anxiety disorders in primary care: study protocol.</ArticleTitle><Pagination><MedlinePgn>320</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12888-018-1898-1</ELocationID><Abstract><AbstractText Label="BACKGROUND">Anxiety disorders are the most common mental disorders in community settings, and they are associated with significant psychological distress, functional and social impairment. While cognitive behaviour therapy (CBT) is the most consistently efficacious psychological treatment for anxiety disorders, barriers preclude widespread implementation of CBT in primary care. Transdiagnostic group CBT (tCBT) focuses on cognitive and behavioural processes and intervention strategies common to different anxiety disorders, and could be a promising alternative to conventional CBT. This study aims to examine the effectiveness of a transdiagnostic group CBT for anxiety disorders program as a complement to treatment-as-usual (TAU) in primary mental health care.</AbstractText><AbstractText Label="METHODS/DESIGN">The trial is a multicentre pragmatic randomized controlled trial with a pre-treatment, post-treatment, and follow-up at 4, 8 and 12-months design. Treatment and control groups. a) tCBT (12 weekly 2-h group sessions following a manualized treatment protocol); b) TAU for anxiety disorders. Inclusion criteria comprise meeting DSM-5 criteria for primary Panic Disorder, Agoraphobia, Social Anxiety Disorder and/or Generalized Anxiety Disorder. Patients are recruited in three regions in the province of Quebec, Canada. The primary outcome measures are the self-reported Beck Anxiety Inventory and the clinician-administered Anxiety and Related Disorders Interview Schedule for DSM-5 (ADIS-5); secondary outcome measures include treatment responder status based on the ADIS-5, and self-reported instruments for specific anxiety and depression symptoms, quality of life, functioning, and service utilisation.</AbstractText><AbstractText Label="STATISTICAL ANALYSIS">Intention-to-treat analysis. A mixed effects regression model will be used to account for between- and within-subject variations in the analysis of the longitudinal effects of the intervention.</AbstractText><AbstractText Label="DISCUSSION">This rigorous evaluation of tCBT in the real world will provide invaluable information to decision makers, health care managers, clinicians and patients regarding the effectiveness of the intervention. Widespread implementation of tCBT protocols in primary care could lead to better effectiveness, efficiency, access and equity for the large number of patients suffering from anxiety disorders that are currently not obtaining evidence-based psychotherapy.</AbstractText><AbstractText Label="TRIAL REGISTRATION">ClinicalTrials.gov: NCT02811458 .</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Roberge</LastName><ForeName>Pasquale</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0001-9929-8393</Identifier><AffiliationInfo><Affiliation>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada. Pasquale.Roberge@USherbrooke.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Provencher</LastName><ForeName>Martin D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>École de psychologie, Pavillon Félix-Antoine-Savard, 2325, rue des Bibliothèques, Université Laval, Québec, QC, G1V 0A6, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gosselin</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institut universitaire de première ligne en santé et services sociaux (CIUSSS de l'Estrie- CHUS), Department of Psychology, Université de Sherbrooke, 2500, boulevard de l'Université, Sherbrooke, QC, J1K 2R1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vasiliadis</LastName><ForeName>Helen-Maria</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Department of Community Health Sciences, Université de Sherbrooke, Centre de recherche Hôpital Charles LeMoyne, 3120, boul. Taschereau, Greenfield Park, QC, J4V 2H1, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaboury</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benoit</LastName><ForeName>Annie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Antony</LastName><ForeName>Martin M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Psychology, Ryerson University, 350 Victoria Street, Toronto, ON, M5B 2K3, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaillet</LastName><ForeName>Nils</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Obstetrics, Gynecology, and Reproduction, Université Laval, 2705, boulevard Laurier, Québec, QC, G1V 4G2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houle</LastName><ForeName>Janie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychology, Université du Québec à Montréal, C.P. 8888, succ. Centre-ville, Montréal, QC, H3C 3P8, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hudon</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS), Department of Family Medicine and Emergency Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, J1H 5N4, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Norton</LastName><ForeName>Peter J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, 18 Innovation Walk, Clayton Campus, Clayton, VIC, 3800, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT02811458</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>340410</GrantID><Agency>CIHR</Agency><Country>Canada</Country></Grant><Grant><GrantID>334091</GrantID><Agency>CIHR</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D065007">Pragmatic Clinical Trial</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>10</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Psychiatry</MedlineTA><NlmUniqueID>100968559</NlmUniqueID><ISSNLinking>1471-244X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000379" MajorTopicYN="N">Agoraphobia</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001008" MajorTopicYN="N">Anxiety Disorders</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015928" MajorTopicYN="N">Cognitive Behavioral Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011320" MajorTopicYN="N">Primary Health Care</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011615" MajorTopicYN="N">Psychotherapy, Group</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="N">Quality of Life</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011792" MajorTopicYN="N" Type="Geographic">Quebec</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057566" MajorTopicYN="N">Self Report</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Access to psychotherapy</Keyword><Keyword MajorTopicYN="Y">Anxiety disorders</Keyword><Keyword MajorTopicYN="Y">Cognitive behaviour therapy</Keyword><Keyword MajorTopicYN="Y">Cost/effectiveness</Keyword><Keyword MajorTopicYN="Y">Evidence-based practice</Keyword><Keyword MajorTopicYN="Y">Group treatment</Keyword><Keyword MajorTopicYN="Y">Pragmatic trial</Keyword><Keyword MajorTopicYN="Y">Primary care</Keyword><Keyword MajorTopicYN="Y">Psychotherapy</Keyword><Keyword MajorTopicYN="Y">Transdiagnostic</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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last="Roberge">Pasquale Roberge</name></noRegion><name sortKey="Antony, Martin M" sort="Antony, Martin M" uniqKey="Antony M" first="Martin M" last="Antony">Martin M. Antony</name><name sortKey="Benoit, Annie" sort="Benoit, Annie" uniqKey="Benoit A" first="Annie" last="Benoit">Annie Benoit</name><name sortKey="Chaillet, Nils" sort="Chaillet, Nils" uniqKey="Chaillet N" first="Nils" last="Chaillet">Nils Chaillet</name><name sortKey="Gaboury, Isabelle" sort="Gaboury, Isabelle" uniqKey="Gaboury I" first="Isabelle" last="Gaboury">Isabelle Gaboury</name><name sortKey="Gosselin, Patrick" sort="Gosselin, Patrick" uniqKey="Gosselin P" first="Patrick" last="Gosselin">Patrick Gosselin</name><name sortKey="Houle, Janie" sort="Houle, Janie" uniqKey="Houle J" first="Janie" last="Houle">Janie Houle</name><name sortKey="Hudon, Catherine" sort="Hudon, Catherine" uniqKey="Hudon C" first="Catherine" last="Hudon">Catherine Hudon</name><name sortKey="Provencher, Martin D" sort="Provencher, Martin D" uniqKey="Provencher M" first="Martin D" last="Provencher">Martin D. Provencher</name><name sortKey="Vasiliadis, Helen Maria" sort="Vasiliadis, Helen Maria" uniqKey="Vasiliadis H" first="Helen-Maria" last="Vasiliadis">Helen-Maria Vasiliadis</name></country><country name="Australie"><noRegion><name sortKey="Norton, Peter J" sort="Norton, Peter J" uniqKey="Norton P" first="Peter J" last="Norton">Peter J. Norton</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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